|
|
|
Annals of Diagnostic Pathology
|
|
2015-04-20
|
|
|
|
|
Annals of Diagnostic Pathology
January 2012 Volume 16, Issue 1, p1-78
For more information, CLICK HERE
Original Contributions
Aysegul Sari, Aylin Calli, Fulya Cakalagaoglu, Aysegul Aksoy Altınboga, Kaan Bal
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.07.001
Published online: October 24 2011
xThis study aims to investigate the relation of mast cell (MC) accumulation with tumor grade and stage in urothelial carcinomas of the urinary bladder and to determine its relationship with angiogenesis. A total of 78 urothelial carcinomas obtained by transurethral resection were investigated immunohistochemically by using c-Kit (CD117) and anti-CD34. The correlation between MC counts and microvessels was evaluated and compared with histopathologic parameters including tumor stage and grade. There were significant correlations between MC counts, grade, and stage (P < .05; r = 0.69 and 0.63, respectively).
Xiaohong Iris Wang, Jaiyeola Thomas, Songlin Zhang
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.07.003
Published online: October 17 2011
xHead and neck squamous cell carcinoma (HNSCC) continues to be a significant disease with varying rates of incidence and mortality worldwide. Numerous studies have demonstrated that human papillomavirus (HPV) is etiologically linked with a subset of HNSCC, independent of tobacco and alcohol use. This subset of tumor shows increased sensitivity to radiation therapy and association with better outcomes. The study aims to determine the HPV burden and trend among patients with HNSCC in the southern region of the United States over the past 10 years.
Norman John Carr, Hannah Leadbetter, Alexandra Marriott
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.08.002
Published online: November 14 2011
xOur aims were to determine the rate of concordance between endoscopic and pathologic diagnoses of gastritis and to determine if there was any common factor in discordant cases. A retrospective analysis of data from 400 patients was performed. The endoscopic diagnoses were compared with the pathologic diagnoses, and histologic slides from discordant cases were reviewed. Of the 400 patients, there was discordance between endoscopy and histology in 136 (34%; κ statistic, 0.31). These discordant cases comprised 56 with normal endoscopy but abnormal histology and 80 with abnormal endoscopy but normal histology.
Charles M. Zaremba, Dwight Oliver, Maryellen Cavalier, Franklin Fuda, Nitin J. Karandikar, Weina Chen
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.07.005
Published online: November 4 2011
xFMS-like tyrosine kinase 3 (FLT3) mutation in T lymphoblastic leukemia/lymphoma (T-LL) is rare (∼4%) and reported only in cases with CD117 expression. This study aimed to identify the immunophenotypic features that may predict FLT3 mutations. We report 3 (43%) of 7 CD117+ T-LL cases harboring FLT3-internal tandem duplication mutation. Compared with 4 FLT3-unmutated cases, all 3 FLT3-mutated cases had a distinct immunophenotype (CD1a−/CD2+/CD7+/CD34+/CD117uniform+/Tdt+) corresponding to the stage of earliest thymic T-cell progenitors possessing myeloid lineage potential.
Preetha Ramalingam, Pablo Zoroquiain, José R. Valbuena, Bonnie L. Kemp, L. Jeffrey Medeiros
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.08.004
Published online: November 7 2011
xLymphoma-like lesion (LLL) of the female genital tract is an older term in the literature that describes a florid reactive lymphoid proliferation that can be misinterpreted as lymphoma. Multiple causes of LLL have been suggested but most cases remain unexplained. We describe the clinicopathologic features of 6 patients with LLL involving the uterine cervix. Five patients presented with abnormal Papanicolaou test (Pap smear), and 3 patients had a biopsy procedure performed prior to detection of LLL in a loop electrosurgical excision procedure (LEEP).
Qing Zhao, Asif Rashid, Yun Gong, Matthew H. Katz, Jeffrey E. Lee, Robert Wolf, Aparna Balachandran, Gauri R. Varadhachary, Peter W. Pisters, Hua Wang, Henry F. Gomez, James L. Abbruzzese, Jason B. Fleming, Huamin Wang
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.08.005
Published online: November 4 2011
xIn patients with pancreatic ductal adenocarcinoma (PDA) who received neoadjuvant therapy and pancreatectomy, pathologic complete response (pCR) is rarely observed and the prognostic significance of pCR is not clear. In this study, we identified 11 patients with pCR (2.5%) from 442 patients with PDA who received neoadjuvant treatment and pancreatectomy from 1995 to 2010. There were 6 men and 5 women, with a median age of 61 years. Four patients had either synchronous or history of extrapancreatic cancer.
Radiologic-Pathologic Correlations
Yusuf Kasirye, Stephen Talsness, Matthew P. Walters, John W.E. Douglas-Jones, Jeffrey M. Resnick, Joseph J. Mazza, Steven H. Yale
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.11.009
Published online: March 11 2011
xThymic cysts (congenital or acquired) are believed to account for 3% to 5% of all mediastinal masses. Multilocular thymic cysts are an acquired reactive inflammatory process arising within the thymus gland and are less common than the congenital unilocular type. Multilocular cysts have been reported in association with a variety of neoplastic, autoimmune, and infectious conditions. We report a case of a 23-year-old white man who presented with a 2-week history of progressive right-sided shoulder and chest pain.
Luisa I. Gómez-Arellano, Tabare Ferrari-Carballo, Hugo R. Domínguez-Malagón
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.08.001
Published online: December 9 2011
xEpithelioid hemangioendothelioma (EHE) is a rare vascular tumor of uncertain biologic behavior. Most cases come out as a single lesion of the soft tissue but also may appear in the lung, liver, and other locations. Epithelioid hemangioendothelioma of bone is an extremely rare tumor and more prevalent in the second and third decades of life; its behavior is uncertain, it most commonly is unifocal, and it affects preferentially lower extremities. In this work, we present the clinical, radiologic, and pathologic findings of a 19-year-old man with a multicentric EHE of bone that involved 3 vertebrae and developed lung metastasis.
Case Reports
Jennifer Chapman-Fredricks, Naomi Montague, Ikechukwu Akunyili, Offiong Ikpatt
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.11.002
Published online: January 18 2011
xPlasmablastic lymphoma (PBL) is an uncommon, clinically aggressive, Epstein-Barr virus–driven B-cell lymphoma that was initially described in tumors of relatively young human immunodeficiency virus–positive men. Subsequent to initial reports, the clinical and pathological spectrum of this disease has been expanded such that, now, PBL is recognized to be a heterogeneous disease entity. Plasmablastic lymphoma has been seen in clinical settings outside those initially reported and has been shown to demonstrate a variety of morphologic patterns.
Natália Dias B. Guimarães, Ana Paula Espindula, Laura Penna Rocha, Janaínna Grazielle Pacheco Olegário, Débora Tavares Resende Silva Abate, Renata Calciolari Rossi e Silva, Camila Lourencini Cavellani, Marlene Antônia dos Reis, Vicente de Paula Antunes Teixeira, Eumenia Costa da Cunha Castro, Rosana Rosa Miranda Corrêa
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.11.004
Published online: February 14 2011
Open Access
xKocher-Debré-Sémélaigne syndrome is a rare disease with little literature, which develops with myopathy in infancy associated with neuromuscular alterations, polymyositis with symmetrical proximal muscle weakness, pseudohypertrophy, muscular rigidity and spasms, exercise intolerance, myxoedema, short stature, and cretinism. Male patient aged 18 years old, 1.52 m in height, admitted in the General Hospital of Triângulo Mineiro Federal University on November 11, 2003, complaining of intense diffuse abdominal pain like severe cramps, without triggering factors, associated with asthenia and hyporexia.
Hanan Farghaly
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.10.001
Published online: February 10 2011
xMucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of kidney tumor that has only been recently described. The classic MTSCCs are polymorphic renal neoplasms characterized by small, elongated tubules lined by cuboidal cells and/or cords of spindled cells separated by pale mucinous stroma. Nonclassic morphologic variants and features of MTSC have not been well studied and rarely been reported. We report a challenging case of mucin-poor MTSCC with marked spindle cell predominance and focal psammomatous calcification in a 39-year-old man and describe its histologic and immunohistochemical features.
Andres A. Roma
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.12.002
Published online: February 10 2011
xWe report a 48-year-old woman presenting with gastric adenocarcinoma metastatic only to the left fallopian tube. In addition to invasive, poorly differentiated adenocarcinoma, there were areas simulating intraepithelial carcinoma, suggesting a primary fallopian tube lesion. The differential diagnosis included a metastatic process, based on unusual morphologic patterns with occasional signet-ring cells, single-cell linear pattern of infiltration, and abundant lymphvascular space invasion. Metastasis from an upper gastrointestinal primary was confirmed by immunostains (cytokeratin 7, CDX-2, and p53 positive in the tumor cells and cytokeratin 20, WT-1, estrogen, and progesterone receptors negative).
Hannah S. van Meurs, Jan J. Dieles, Herbert V. Stel
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2010.11.010
Published online: January 10 2011
xLeiomyosarcoma of the uterus is a rare tumor, and the presence of osteoclast-like giant cells in this tumor is even rarer. A leiomyosarcoma arising in a leiomyoma is also quite unique. Breast cancer metastasizing to the uterus is seldom seen as well. A 70-year-old woman presented with metastasized breast cancer to the bones. An evaluation of the computed tomographic scan was made, which showed an enlarged uterus with a tumor. The tumor was a leiomyoma in which a leiomyosarcoma with osteoclast-like giant cells as well as a metastasis of a ductal breast carcinoma was present.
History of Pathology
Mark R. Wick
DOI: http://dx.doi.org/10.1016/j.anndiagpath.2011.10.010
xHistochemistry has an interesting history, extending back to ancient times, in some ways. Man has long had a desire to understand the workings of the human body and the roles that various “humors” or chemicals have in those processes. This review traces the evolution of histochemistry as an investigative and diagnostic discipline, beginning with the efforts of medicinal chemists and extending through a period in which histology was increasingly paired with biochemistry. Those developments served as the underpinnings for an eventual marriage of microscopy, chemistry, immunology, and molecular biology, as realized in the current practice of anatomical pathology.
DOI: http://dx.doi.org/10.1016/S1092-9134(11)00182-1
Frontmatter
DOI: http://dx.doi.org/10.1016/S1092-9134(11)00181-X
DOI: http://dx.doi.org/10.1016/S1092-9134(11)00179-1
|
|
|