OncoTarget 500

Molecular
505-gene panel + MSI & TMB for advanced solid tumors

Panel details:
ABL1, ABL2, ACVR1, ACVR1B, ADORA2A, AKT1, AKT2, AKT3, ALK*, ALOX12B, AMER1, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BBC3, BCL2, BCL2L1, BCL2L2, BCL2L11, BCL6, BCOR, BCORL1, BCR, BIRC2, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTG2, BTK, BUB1B, C11ORF30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD22, CD70, CD79A, CD79B, CD274, CD276, CDC73, CDH1, CDK4, CDK6, CDK8, CDK12, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CHD4, CHEK1, CHEK2, CIC, CREBBP, CRKL, CSF1, CSF1R, CSF2, CSF3, CSF3R, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUL4A, CXCR2, CXCR4, CYLD, CYP17A1, DAXX, DCUN1D1, DDB2, DDR1, DDR2, DICER1, DIS3, DNMT1, DNMT3A, DNMT3B, DOT1L, E2F3, EED, EGFL7, EGFR, EIF1AX, EP300, EPAS1, EPCAM, EPHA2, EPHA3, EPHA5, EPHA7, EPHB1, EPHB4, ERBB2#, ERBB3, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, ERG, ERRFI1, ESR1, ETV1, ETV4, ETV5, ETV6, EWSR1, EXT1, EXT2, EZH2, FAM46C, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FBXW7, FGF3, FGF4, FGF6, FGF10, FGF12, FGF14, FGF19, FGF23, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXP1, FRS2, FUBP1, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GPC3, GPR124, GREM1, GRIN2A, GRM3, GSK3B, H3F3A, H3F3B, H3F3C, HDAC1, HDAC2, HDAC6, HGF, HIST1H1C, HIST1H2BD, HIST1H3B, HNF1A, HRAS, HSD3B1, HSP90AA1, HSP90AB1, ICOSLG, ID3, IDH1, IDH2, IFNGR1, IGF1, IGF1R, IGF2, IGF2R, IKBKE, IKZF1, IL7R, IL10, INHBA, INPP4A, INPP4B, INSR, IRF2, IRF4, IRS1, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIT, KLF4, KLHL6, KMT2A, KMT2C, KMT2D, KRAS, LATS1, LATS2, LMO1, LRP1B, LTK, LYN, LZTR1, MAF, MAGI2, MAML1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAPK1, MAX, MCL1, MDC1, MDM2, MDM4, MED12, MEF2B, MEN1, MERTK, MET, MITF, MKNK1, MLH1, MLH3, MPL, MRE11A, MSH2, MSH3, MSH6, MST1R, MTAP, MTOR, MUTYH, MYB, MYC, MYCL, MYCN, MYD88, MYOD1, NBN, NCOA3, NCOR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NSD1, NT5C2, NTRK1, NTRK2*, NTRK3*, NUP93, NUTM1, PAK1, PAK3, PAK7, PALB2, PARK2, PARP1, PARP2, PARP3, PAX5, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PDPK1, PHOX2B, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCG2, PLK2, PMAIP1, PMS1, PMS2, PNRC1, POLD1, POLE, POLH, POT1, PPARG, PPP2R1A, PPP2R2A, PRDM1, PREX2, PRKAR1A, PRKCI, PRKDC, PRSS1, PRSS8, PTCH1, PTEN, PTK2, PTPN11, PTPRD, PTPRO, PTPRS, PTPRT, QKI, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54B, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL4, REL, RET*, RFWD2, RHOA, RICTOR, RIT1, RNF43, ROS1, RPA1, RPS6KA4, RPS6KB2, RPTOR, RUNX1, RUNX1T1, RYBP, SBDS, SDHA, SDHAF2, SDHB, SDHC, SDHD, SETD2, SF3B1, SGK1, SH2D1A, SHQ1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMARCD1, SMO, SNCAIP, SOCS1, SOX2, SOX9, SOX10, SOX17, SPEN, SPOP, SPTA1, SRC, STAG2, STAT3, STAT4, STK11, STK40, SUFU, SUZ12, SYK, TAF1, TBX3, TEK, TERC, TERT, TET1, TET2, TGFBR1, TGFBR2, TIPARP, TLR4, TLR7, TLR8, TLR9, TMEM127, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP53BP1, TP63, TRAF7, TSC1, TSC2, TSHR, TYRO3, U2AF1, VEGFA, VHL, VTCN1, WAS, WEE1, WHSC1, WHSC1L1, WISP3, WRN, WT1, XIAP, XPA, XPC, XPO1, XRCC1, XRCC2, XRCC3, YAP1, YES1, ZBTB2, ZNF217, ZNF703

Average TAT: 7-10 days

CPT Code(s): 81479/0250U/81455 depending on Insurance

Specimen Requirements: FFPE block or 10-15 unstained slides

Methodology: NGS

Disease Group: Solid tumor