NTRK 1, NTRK 2, NTRK 3
*MSIHIGH
^TMBHIGH
KRAS(wildtype)
BRAF V600E
NRAS
KIT
BRAF V600E/K
BRAF V600
BRCA1, BRCA2
FDA-APPROVED THERAPY:
Lynparza® (olaparib) or Rubraca® (rucaparib)
ATM, BARD1, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54L
BRCA1, BRCA2
SMARCB1 (epithelioid)
COL1A1-PDGFB fusion (dermatofibrosarcoma protuberans)
FDA-APPROVED THERAPY:
Cosmegen (Dactinomycin), Dactinomycin, Doxorubicin Hydrochloride, Eribulin Mesylate, Gleevec (Imatinib Mesylate), Halaven (Eribulin Mesylate), Imatinib Mesylate, Pazopanib Hydrochloride, Tazemetostat Hydrobromide, Tazverik (Tazemetostat Hydrobromide), Trabectedin, Votrient (Pazopanib Hydrochloride), Yondelis (Trabectedin)
BRAF v600E (anaplastic)
RET (Medullary)